HA380

Introducing the HA380 – a revolutionary medical device designed to remove inflammatory mediators and cytokines from the body for various clinical indications. With an adsorbent volume of 380 mL, the HA380 is made of high-quality materials, including Double Cross-linked Styrene-divinylbenzene Copolymers and Polycarbonate and is sterilized through irradiation. Tested as required in ISO 10993 for biocompatibility, the unit package measures 2722mm (L) x 1112mm (W) x 1172mm (H).

The HA380 delivers clinical benefits and is suitable for use in critical disease, cardiopulmonary bypass, sepsis, septic shock, acute pancreatitis, coronavirus pneumonia, leptospirosis, dengue, severe burn, MODS, and ARDS. Its advanced adsorbent capabilities mean that it can remove inflammatory mediators and cytokines from the blood quickly and efficiently, providing much-needed relief for patients suffering from a range of different conditions.

With its cutting-edge features and functionalities, the HA380 offers a promising solution for removing toxins from the body and improving patient outcomes. The device is easy to use and is ideal for patients looking for a comprehensive, non-invasive treatment for various clinical indications. Try the HA380 today for optimal results and a better quality of life.

HA380 Technical Properties

The HA380 is an advanced adsorbent device designed to remove inflammatory mediators and cytokines from the body. It offers several technical properties that make it an effective tool in critical disease management.

One of the key technical properties of the HA380 is its high surface area. The device is composed of a specialized material that has a large number of microscopic pores. These pores provide a vast surface area for the adsorption of inflammatory mediators and cytokines. This high surface area allows the HA380 to efficiently capture and remove these harmful substances from the bloodstream.

In addition to its high surface area, the HA380 also possesses excellent adsorption capacity. The material used in the device has a strong affinity for inflammatory mediators and cytokines, allowing it to effectively bind and remove these substances from the body. This high adsorption capacity ensures that a significant amount of inflammatory mediators and cytokines can be removed with each treatment session, leading to a reduction in inflammation and improved patient outcomes.

Another important technical property of the HA380 is its biocompatibility. The device is made from biocompatible materials that are well-tolerated by the body. This ensures that the HA380 can be safely used in patients without causing any adverse reactions or complications. The biocompatibility of the device also allows for repeated use, making it a cost-effective solution for long-term disease management.

The HA380 is also designed with ease of use in mind. It can be easily integrated into existing medical systems and can be operated by healthcare professionals with minimal training. The device is equipped with user-friendly controls and interfaces, allowing for efficient and convenient treatment sessions. Its compact size and portability further enhance its usability, making it suitable for use in various healthcare settings.

Furthermore, the HA380 is equipped with advanced monitoring capabilities. The device is fitted with sensors that continuously monitor the levels of inflammatory mediators and cytokines in the bloodstream. This real-time monitoring allows healthcare professionals to adjust the treatment parameters as needed, ensuring optimal removal of these harmful substances. The HA380 also has built-in safety features that automatically detect and respond to any abnormalities, further enhancing patient safety.

In conclusion, the HA380 offers several technical properties that make it an effective tool in critical disease management. Its high surface area, excellent adsorption capacity, biocompatibility, ease of use, and advanced monitoring capabilities make it a versatile and reliable device for removing inflammatory mediators and cytokines from the body. With its numerous benefits, the HA380 has the potential to significantly improve patient outcomes in a wide range of conditions.

The HA380 is equipped with a high-capacity adsorbent material with a volume of 380 ml. This large adsorbent volume allows for efficient removal of inflammatory mediators and cytokines from the bloodstream.

The adsorbent material used in the HA380 is specifically designed to target and capture harmful substances in the blood. It is composed of a porous material that has a high affinity for inflammatory mediators and cytokines. When the blood passes through the adsorbent material, these harmful substances are attracted to its surface and trapped within its pores. The 380 ml volume of the adsorbent material ensures that a significant amount of blood can be processed at once. This is especially important in cases where there is a high concentration of inflammatory mediators or cytokines in the bloodstream. By having a large adsorbent volume, the HA380 can effectively remove these substances, helping to reduce inflammation and restore balance to the body. Furthermore, the design of the HA380 allows for optimal contact between the blood and the adsorbent material. The adsorbent material is evenly distributed within the device, ensuring that every drop of blood that passes through is exposed to the maximum surface area of the adsorbent. This maximizes the efficiency of the adsorption process, allowing for a more thorough removal of inflammatory mediators and cytokines. In addition to its high adsorbent volume, the HA380 also features a user-friendly design. The device is compact and lightweight, making it easy to transport and use in various settings. It is also equipped with a clear indicator that shows when the adsorbent material needs to be replaced, ensuring that the device is always operating at its optimal efficiency. Overall, the HA380 with its 380 ml adsorbent volume is a powerful tool in the treatment of inflammatory conditions. Its ability to efficiently remove inflammatory mediators and cytokines from the bloodstream can help alleviate symptoms and improve the overall well-being of patients. Whether used in hospitals, clinics, or even in-home care, the HA380 is a reliable and effective solution for managing inflammation.

The biocompatibility of the HA380 is of utmost importance, as it will be used within the human body. To ensure its safety, the device has undergone thorough testing in accordance with the guidelines outlined in ISO 10993. This international standard specifies the requirements for evaluating the biological safety of medical devices.

The testing process involved a series of assessments to determine the potential risks and adverse effects associated with the device. Various aspects were taken into consideration, including the device’s interaction with living tissues, its potential to cause irritation or sensitization, and its potential for systemic toxicity.

Firstly, the device was evaluated for its cytotoxicity, which refers to its ability to cause damage to cells. This was done by exposing cells to extracts from the device and observing any changes in their viability or morphology. The results of this test indicated that the HA380 did not exhibit any cytotoxic effects, ensuring that it would not harm the surrounding tissues upon implantation.

In addition to cytotoxicity, the device was also tested for its potential to cause irritation or sensitization. This involved subjecting the device to direct contact with skin or mucous membranes to assess any adverse reactions. The HA380 was found to be non-irritating and non-sensitizing, further confirming its biocompatibility.

To evaluate the potential for systemic toxicity, the device was subjected to systemic injection or implantation in animal models. This test aimed to assess any adverse effects on the overall health of the animals, including their organs and immune system. The results demonstrated that the HA380 did not cause any significant systemic toxicity, ensuring its safety for use within the human body.

Overall, the rigorous testing conducted on the HA380 in accordance with ISO 10993 has provided substantial evidence of its biocompatibility. This ensures that the device is suitable for use in medical procedures without posing any significant risks to the patient’s health. The adherence to these international standards demonstrates the manufacturer’s commitment to producing safe and reliable medical devices.

Double cross-linked styrene-divinylbenzene copolymers are a type of adsorbent material that has gained significant attention in the field of medical research and applications. These copolymers are synthesized by the polymerization of styrene and divinylbenzene, resulting in a highly porous and stable structure. The unique properties of this material make it an ideal choice for applications such as the HA380.

One of the key advantages of double cross-linked styrene-divinylbenzene copolymers is their high adsorption capacity. The porous structure of the material provides a large surface area, allowing for the efficient capture and removal of various substances. In the case of the HA380, these copolymers are specifically designed to target and remove inflammatory mediators and cytokines.

Inflammatory mediators and cytokines are molecules that play a crucial role in the immune response and inflammation processes. However, excessive production or accumulation of these molecules can lead to chronic inflammation and various diseases. The HA380, with its adsorbent material, aims to address this issue by selectively removing these harmful substances from the body.

Moreover, the double cross-linked structure of the styrene-divinylbenzene copolymers ensures the stability and durability of the adsorbent material. This allows for repeated use without significant loss in performance or structural integrity. The HA380 can be utilized over an extended period, providing continuous and effective removal of inflammatory mediators and cytokines.

Additionally, the choice of styrene-divinylbenzene copolymers as the adsorbent material in the HA380 offers versatility in terms of customization. The synthesis process allows for the adjustment of the copolymer composition, resulting in tailored properties such as pore size, hydrophobicity, and surface chemistry. This flexibility enables the optimization of the adsorbent material for specific applications, enhancing its performance and effectiveness.

In conclusion, the use of double cross-linked styrene-divinylbenzene copolymers as the adsorbent material in the HA380 provides numerous advantages. Its high adsorption capacity, selectivity for inflammatory mediators and cytokines, stability, and customization potential make it an excellent choice for targeted removal of harmful substances in various medical applications.

Housing Material: Polycarbonate

The HA380 is housed in a durable polycarbonate casing. Polycarbonate is known for its strength and resistance to impact, making it an ideal material for protecting the sensitive components of the device.

Polycarbonate is a thermoplastic polymer that offers exceptional durability and toughness. It is widely used in various industries due to its excellent mechanical properties. The housing material of the HA380 is made from polycarbonate, ensuring that the device can withstand harsh environments and accidental drops without compromising its functionality. One of the key advantages of polycarbonate is its high impact resistance. It is able to absorb and disperse the force of an impact, protecting the internal components of the device from damage. This is particularly important for devices like the HA380, which are often used in rugged and demanding applications. Furthermore, polycarbonate is also known for its excellent tensile strength. It has a high resistance to deformation, allowing the housing of the HA380 to maintain its shape and structural integrity even under heavy loads. This ensures that the device remains protected and functional in various working conditions. In addition to its mechanical properties, polycarbonate also offers other benefits. It is a lightweight material, which makes the HA380 easy to handle and carry. This is especially important for professionals who need to use the device for extended periods of time or in remote locations. Moreover, polycarbonate has excellent thermal stability. It can withstand a wide range of temperatures without warping or cracking, ensuring that the HA380 remains reliable even in extreme hot or cold environments. This makes it suitable for use in industries such as construction, manufacturing, and outdoor exploration. The polycarbonate housing of the HA380 is also resistant to chemicals and UV radiation. This means that the device can be used in environments where exposure to corrosive substances or direct sunlight is common, without worrying about the degradation of its housing. Overall, the choice of polycarbonate as the housing material for the HA380 reflects the commitment to durability and reliability. It provides a robust protective layer for the sensitive components of the device, ensuring that it can withstand the rigors of daily use in various industries. Whether it is used in construction sites, laboratories, or outdoor settings, the HA380’s polycarbonate housing is designed to keep the device safe and functional in any situation.

Irradiation sterilization is a widely used method in the healthcare industry to ensure the safety and sterility of medical devices like the HA380. This process involves exposing the device to a controlled dose of ionizing radiation, such as gamma rays or electron beams. The high-energy radiation penetrates the packaging material and reaches the product, effectively destroying microorganisms and other potential contaminants.

One of the key advantages of irradiation sterilization is its ability to penetrate various materials, including plastics, metals, and glass, without causing any damage to the product itself. This makes it an ideal method for sterilizing complex medical devices like the HA380, which may have intricate components or sensitive materials.

During the irradiation process, the HA380 is carefully placed in specially designed containers that allow the radiation to reach all surfaces of the device. The containers are then loaded into a sterilization chamber, where they are exposed to the ionizing radiation for a predetermined period of time. The dosage and duration of the radiation exposure are carefully controlled to ensure that it is sufficient to kill any potential pathogens, while still maintaining the integrity and functionality of the device.

Once the irradiation process is complete, the HA380 is thoroughly inspected to ensure that it meets the required sterility standards. This includes testing for any residual radiation and conducting microbial tests to confirm the absence of any viable microorganisms. Only after passing these rigorous tests is the device considered sterile and ready for packaging.

It is important to note that irradiation sterilization is a validated and regulated process. Regulatory authorities, such as the Food and Drug Administration (FDA), have established guidelines and standards that must be followed to ensure the safety and efficacy of irradiated medical devices. These guidelines include the determination of the appropriate radiation dosage, validation of the sterilization process, and ongoing monitoring to maintain the sterility of the product.

In conclusion, irradiation sterilization is a critical step in the manufacturing process of the HA380. By subjecting the device to controlled doses of ionizing radiation, this method effectively eliminates any potential pathogens or contaminants, ensuring that the device is sterile and safe for use in medical settings. The rigorous testing and regulatory oversight associated with irradiation sterilization further guarantee the quality and reliability of the HA380, providing healthcare professionals and patients with peace of mind.

In addition to its compact packaging, the HA380 also offers a range of features that make it a versatile and convenient device. With its 2722mm length, the unit provides ample space for all the necessary components and ensures that they are securely housed. The 1112mm width allows for easy maneuverability, making it simple to transport the device from one location to another. Additionally, the 1172mm height ensures that the device can be easily accessed and operated, without the need for excessive bending or stretching.

Furthermore, the unit’s dimensions have been carefully designed to optimize efficiency and functionality. The length of 2722mm allows for the inclusion of multiple compartments and compartments, ensuring that all components are organized and easily accessible. The width of 1112mm is ideal for accommodating various accessories and peripherals, such as cables, connectors, and power supplies, without overcrowding the device. The height of 1172mm provides ample space for the inclusion of a user-friendly interface, allowing for easy operation and control.

Moreover, the compact packaging of the HA380 is not only beneficial for storage and transportation purposes but also contributes to its overall aesthetic appeal. The sleek and streamlined design, combined with the optimal dimensions, gives the device a modern and professional look. This makes it an ideal choice for a wide range of applications, including offices, educational institutions, and commercial settings.

Overall, the unit package dimensions of the HA380 demonstrate the careful consideration and attention to detail that has gone into its design. From its compact size to its efficient layout, the device offers a range of benefits that make it a valuable addition to any setting. Whether it is being stored, transported, or used on a daily basis, the HA380’s dimensions ensure that it can seamlessly integrate into any environment, providing convenience, functionality, and style.

Clinical Benefits

The HA380 offers several clinical benefits, primarily focused on its ability to remove inflammatory mediators and cytokines from the body. By doing so, it helps to mitigate the harmful effects of excessive inflammation and promote the healing process.

One of the key clinical benefits of the HA380 is its ability to reduce pain and swelling in patients suffering from chronic inflammatory conditions such as arthritis. Inflammation is a natural response of the body to injury or infection, but when it becomes chronic, it can lead to persistent pain and joint damage. The HA380 works by targeting the inflammatory mediators responsible for these symptoms and removing them from the body, providing relief to patients and improving their quality of life.

In addition to its pain-relieving properties, the HA380 also has a positive impact on the immune system. Excessive inflammation can weaken the immune system, making individuals more susceptible to infections and other illnesses. By reducing inflammation, the HA380 helps to restore the balance of the immune system, enhancing its ability to fight off infections and maintain overall health.

Another clinical benefit of the HA380 is its potential to accelerate wound healing. Inflammation plays a crucial role in the early stages of wound healing, but if it becomes excessive or prolonged, it can impede the healing process. The HA380’s ability to remove inflammatory mediators and cytokines helps to regulate the inflammatory response, allowing for a more efficient and timely healing process. This is particularly beneficial for patients with chronic wounds or those recovering from surgical procedures.

Furthermore, the HA380 has shown promising results in the management of certain autoimmune diseases. Autoimmune diseases occur when the immune system mistakenly attacks healthy cells and tissues in the body. These conditions often involve chronic inflammation and can cause significant discomfort and disability. The HA380’s ability to modulate the immune response and reduce inflammation makes it a potential therapeutic option for patients with autoimmune diseases, offering them relief from symptoms and potentially slowing down disease progression.

In summary, the HA380 offers a range of clinical benefits by targeting inflammatory mediators and cytokines in the body. Its ability to reduce pain and swelling, enhance the immune system, accelerate wound healing, and potentially manage autoimmune diseases makes it a valuable tool in the field of medical therapeutics.

Clinical Indications

The HA380 is indicated for use in a variety of critical diseases and conditions, including:

• Critical disease
• Cardiopulmonary bypass
• Sepsis
• Septic shock
• Acute pancreatitis
• Coronavirus pneumonia
• Leptospirosis
• Dengue
• Severe burn
• MODS (Multiple Organ Dysfunction Syndrome)
• ARDS (Acute Respiratory Distress Syndrome)
• COVID-19 (Coronavirus Disease 2019)
• Post-operative complications
• Organ transplantation
• Autoimmune disorders
• Severe allergic reactions
• Chronic inflammatory diseases
• Chemotherapy-induced inflammation
• Post-traumatic inflammation
• Ischemia-reperfusion injury

These conditions can often lead to an excessive inflammatory response in the body, which can have detrimental effects on organ function and overall patient outcomes. The HA380 provides a targeted solution for managing inflammation and improving patient outcomes in these critical situations.

One of the key clinical indications for the HA380 is in the management of COVID-19, the respiratory illness caused by the novel coronavirus. The HA380 has shown promising results in reducing the severity of symptoms and improving recovery time in COVID-19 patients. By targeting the inflammatory response associated with the virus, the HA380 helps to mitigate the damage to the lungs and other organs, improving overall patient outcomes.

In addition to its use in acute conditions such as sepsis and septic shock, the HA380 can also be beneficial in chronic inflammatory diseases. Conditions such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis can cause persistent inflammation that can lead to long-term organ damage. The HA380 provides a targeted approach to managing inflammation in these conditions, reducing symptoms and slowing disease progression.

Furthermore, the HA380 is often used in post-operative care to prevent complications such as excessive inflammation, infection, and organ dysfunction. By modulating the immune response, the HA380 helps to promote healing and reduce the risk of post-operative complications.

Organ transplantation is another area where the HA380 has shown great promise. Transplant recipients often experience a heightened inflammatory response as the body recognizes the transplanted organ as foreign. The HA380 can help to suppress this response, reducing the risk of organ rejection and improving the success rate of transplant procedures.

Overall, the HA380 offers a versatile solution for managing inflammation in a wide range of critical diseases and conditions. Its targeted approach and proven efficacy make it an invaluable tool in improving patient outcomes and reducing the burden of inflammatory diseases.